Benjamin Herzberg, MD
Assistant Professor of Medicine
Department of Medicine, Hematology & Oncology
Program: Precision Oncology and Systems Biology (POSB)
Carla Concepcion-Crisol, PhD
Assistant Professor of Molecular Pharmacology and Therapeutics
Department of Molecular Pharmacology & Therapeutics
Program: Cancer Genomics and Epigenomics (CGE)
Title: Deconstructing SWI/SNF alterations in non-small cell lung cancer
Description: Alterations in genes encoding for subunits of SWI/SNF chromatin remodeling complexes occur in ~30% of non-small cell lung cancers, largely lung adenocarcinomas. These alterations are often associated with poor patient outcomes in cancer. Here, we will discuss the overall prognostic role of individual SWI/SNF subunit alterations in all NSCLCs and in oncogenic driver-positive (D+) and driver-negative (D-) groups. We will describe ongoing efforts in the laboratory to mechanistically interrogate the impact of SWI/SNF alterations on lung cancer progression and therapeutic responses. Finally, we will discuss targeted therapies for SWI/SNF-mutant cancers currently in clinical trials.
Join Zoom Meeting
https://columbiacuimc.zoom.us/j/98062087107?pwd=ODN1TFwbtR23dO0Pk7Bq73td7fG91L.1
Meeting ID: 980 6208 7107
Passcode: 267022
