Sergei Doulatov, PhD
Associate Professor of Physiology and Cellular Biophysics
Department of Physiology & Cellular Biophysics
Program: Cancer Genomics and Epigenomics
Title: Insights into leukemia evolution from pluripotent stem cell models
Description: Myeloid malignancies arise as a result of extended preleukemic clonal evolution of human hematopoietic stem cells (HSCs). Over the past decade, cancer genome sequencing efforts have identified the major genetic drivers of leukemic transformation. A key goal is now to understand how these driver mutations cooperate at the molecular level to confer competitive clonal advantage to HSCs. My lab is developing models of preleukemia and myelodysplastic syndromes (MDS), especially utilizing patient-derived induced pluripotent stem cells (iPSCs). In this talk, I will present ongoing efforts in my lab to uncover novel mechanisms by which driver mutations promote leukemic transformation and efforts towards developing targeted therapies.
Join Zoom Meeting
https://columbiacuimc.zoom.us/j/98062087107?pwd=ODN1TFwbtR23dO0Pk7Bq73td7fG91L.1
Meeting ID: 980 6208 7107
Passcode: 267022
