Dr. Michael Petriello
Assistant Professor in Pharmacology
Wayne State University
The goals of his research are directly relatable to understanding mechanisms that link nutrition and toxicology and may lead to translatable prevention strategies that may limit pollutant-induced metabolic disorders such as diabetes, obesity, and cardiovascular disease, especially in at-risk populations. He also has strong experience and interest in using large data sets to uncover novel associations of environmental risk and cardiovascular disease as well as working with underserved communities that face multiple chemical and non-chemical stressors.
Overall, he aims to investigate biomarkers that link environmental exposures, diet, and metabolic diseases in human populations and to test mechanisms of toxicity using mouse models of cardiometabolic disease.
Seminar Title: PFAS mixtures induce placental toxicity and modulate fetal growth and metabolism
Abstract: Per- and polyfluoroalkyl substances (PFAS) have been associated with preterm birth and related reproductive outcomes in humans. Although multiple mechanisms of toxicity have been implicated, the placenta likely plays an important role in the toxicity of a wide variety of environmental exposures. Recent work has identified the existence of a sexual dimorphic response to PFAS exposure in male and female placentas which may help to explain why certain offspring effects are also sex specific. This presentation will focus on recent mechanistic maternal exposure studies conducted by Dr. Mike Petriello at Wayne State University in Detroit, Michigan who is affiliated with their NIEHS-funded P30 and P42 as well as the Michigan ECHO-2 site.
Zoom registration link: https://columbiacuimc.zoom.us/meeting/register/h102nNwvRAuBsrdWEhXzXA
